AUTOINMUNIDAD NEUROLÓGICA EN LOS TIEMPOS DEL ZIKA
Palabras clave:
Zika, autoinmunidad, Síndrome de Guillain-Barré, gangliósidos, ecología autoinmune, Zika virus, autoimmunity, Guillain-Barré syndrome, gangliosides, autoimmune ecologyResumen
Desde el año 2015 el mundo se vio enfrentado al renacer de una nueva epidemia por el virus del Zika (vZIKA), cuyas complicaciones neurológicas hicieron que en Febrero de 2016 la Organización Mundial de la Salud declarara la epidemia como una “emergencia de salud pública de importancia internacional”. En el presente artículo se revisan las características de este virus y su asociación con el síndrome de Guillain-Barré, a través de una posible respuesta autoinmune contra gangliósidos mediante mimetismo molecular, en el contexto de la ecología autoinmune.
NEUROLOGICAL AUTOIMMUNITY IN THE TIME OF ZIKA
ABSTRACT
Since 2015 the world is facing a new outbreak of Zika virus (ZIKV). The sudden increase in neurological complications associated with ZIKV prompted the World Health Organization to declare this outbreak in February 2016 a “public health emergency of international concern”. This article reviews the main characteristics of ZIKV and its association with Guillain-Barre syndrome, in the context of autoimmune ecology, through a possible molecular mimicry against gangliosides.
Biografía del autor/a
Yeny Acosta-Ampudia, Universidad del Rosario
Diana M. Monsalve, Universidad del Rosario
Yhojan Rodríguez, Universidad del Rosario
María L. Gunturiz, Instituto Nacional de Salud
Carolina Ramirez-Santana, Universidad del Rosario
Diana C. González-Bravo, Universidad del Rosario
Mónica Rodríguez-Jiménez, Universidad del Rosario
Adriana Rojas-Villarraga, Universidad del Rosario
Pablo Chaparro, Instituto Nacional de Salud
Juan-Manuel Anaya, Universidad del Rosario
Referencias bibliográficas
Hennessey M, Fischer M, Staples JE. Zika virus spreads to new areas — Region of the Americas, May 2015–January 2016. MMWR Morb Mortal Wkly Rep 2016;65:55–8.
Chang C, Ortiz K, Ansari A, Gershwin M. The Zika out- break of the 21st century. J Autoimmun 2016;68:1–13.
WHO. Zika Americas. Wkly Epidemiol Rec 2015:609– 16.
Musso D, Nilles EJ, Cao-Lormeau VM. Rapid spread of emerging Zika virus in the Pacific area. Clin Microbiol Infect 2014;20:O595–6.
Zanluca C, de Melo VCA, Mosimann ALP, dos Santos GIV, dos Santos CND, Luz K. First report of autochthonous transmission of Zika virus in Brazil. Mem Inst Oswaldo Cruz 2015;110:569–72.
Lednicky J, Beau De Rochars VM, El Badry M, Loeb J, Telisma T, Chavannes S, et al. Zika Virus outbreak in Haiti in 2014: Molecular and clinical data. PLoS Negl Trop Dis 2016;10:e0004687.
Instituto Nacional de Salud. Boletín Epidemiológico Semanal, número 27 de 2016 ( 03 julio - 09 julio) http://www.ins.gov.co/boletin epidemiologico/Bo- letn%20Epidemiolgico/2016%20Bolet%C3%ADn%20 epidemiol%C3%B3gico%20semana%2027.pdf
Rasmussen SA, Jamieson DJ, Honein MA, Petersen LR. Zika virus and birth defects - reviewing the evidence for causality. N Engl J Med 2016;374:1981-7.
Sharp TM, Muñoz-Jordán J, Perez-Padilla J, Bello- Pagán MI, Rivera A, Pastula DM et al. Zika Virus infection associated with severe thrombocytopenia. Clin Infect Dis. 2016 Jul 14. pii: ciw476. [Epub ahead of print].
Rodriguez-Morales AJ, Villamil-Gómez WE, Franco- Paredes C. The arboviral burden of disease caused by co-circulation and co-infection of dengue, chikungunya and Zika in the Americas. Travel Med Infect Dis 2016;14:177-9.
Faye O, Freire CC, Iamarino A, Faye O, de Oliveira JV, Diallo M, et al. Molecular evolution of Zika virus during its emergence in the 20(th) century. PLoS Negl Trop Dis 2014;8:e2636.
Lanciotti RS, Lambert AJ, Holodniy M, Saavedra S, Signor Ldel C. Phylogeny of Zika virus in western hemisphere, 2015. Emerg Infect Dis. 2016;22:933-5.
Wang L, Valderramos SG, Wu A, Ouyang S, Li C, Brasil P, et al. From mosquitos to humans: genetic evolution of Zika virus. Cell Host Microbe 2016;19:561-5.
Zhu Z, Chan JF, Tee KM, Choi GK, Lau SK, Woo PC, et al. Comparative genomic analysis of pre-epidemic and epidemic Zika virus strains for virological factors potentially associated with the rapidly expanding epidemic. Emerg Microbes Infect 2016;5:e22.
Dejnirattisai W, Supasa P, Wongwiwat W, Rouvinski A, Barba-Spaeth G, Duangchinda T, et al. Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus. Nat Immunol. 2016 Jun 23.
Anaya J-M. Common mechanisms of autoimmune diseases (the autoimmune tautology). Autoimmun Rev 2012;11:781-4.
Anaya J-M, Ramirez-Santana C, Alzate MA, Molano- Gonzalez N, Rojas-Villarraga A. The autoimmune ecology. Front Immunol 2016;7:139.
Wild CP. The exposome: from concept to utility. Int J Epidemiol 2012;41:24-32.
Okada H, Kuhn C, Feillet H, Bach JF. The “hygiene hypothesis” for autoimmune and allergic diseases: an update. Clin Exp Immunol 2010;160:1-9.
Saeki Y, Ishihara K. Infection–immunity liaison: Pathogen-driven autoimmune-mimicry (PDAIM). Autoimmun Rev 2014;13:1064-9.
Christen U, Hintermann E, Holdener M, von Herrath MG. Viral triggers for autoimmunity: is the ‘glass of molecular mimicry’ half full or half empty? J Autoim- mun. 2010;34:38-44.
Jasti AK, Selmi C, Sarmiento-Monroy JC, Vega DA, Anaya JM, Gershwin ME. Guillain-Barré syndrome: causes, immunopathogenic mechanisms and treatment. Expert Rev Clin Immunol. 2016 Jun 21:1-15. [Epub ahead of print]
Yang B, Lian Y, Liu Y, Wu BY, Duan RS. A retrospective analysis of possible triggers of Guillain-Barre syndrome. J Neuroimmunol 2016;293:17-21
Mahecha MP, Ojeda E, Vega DA, Sarmiento-Monroy JC, Anaya JM. Guillain–Barré syndrome in Colombia: where do we stand now? Immunol Res 2016 Jul 15. [Epub ahead of print].
Paixão ES, Barreto F, Teixeira Mda G, Costa Mda C, Rodrigues LC. History, Epidemiology, and clinical manifestations of zika: a systematic review. Am J Public Health 2016;106:606-12.
Thomas SM, Tjaden NB, van den Bos S, Beierkuhnlein C. Implementing cargo movement into climate based risk assessment of vector-borne diseases. Int J Environ Res Public Health 2014;11:3360-74.
Ai JW, Zhang Y, Zhang W. Zika virus outbreak: ‘a perfect storm’. Emerg Microbes Infect 2016;5:e21.
Imperato PJ. The convergence of a virus, mosquitoes, and human travel in globalizing the Zika epidemic. J Community Health. 2016 Jun;41(3):674-9.
Oehler E, Watrin L, Larre P, Leparc-Goffart I, Lastere S, Valour F, et al. Zika virus infection complicated by Guillain-Barre syndrome--case report, French Polynesia, December 2013. Euro Surveill 2014;19:7–9.
Cao-Lormeau V, Blake A, Mons S, Lastère S, Roche C, Vanhomwegen J, et al. Guillain-Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study. Lancet 2016;387:1531-9.
Cauchemez S, Besnard M, Bompard P, Dub T, Guillemette-artur P, Eyrolle-guignot D, et al. Association between Zika virus and microcephaly in French Polynesia, 2013-15: a retrospective study. Lancet 2016;387:2125-32.
Ye Q, Liu ZY, Han JF, Jiang T, Li XF, Qin CF. Genomic characterization and phylogenetic analysis of Zika virus circulating in the Americas. Infect Genet Evol 2016;43:43-9.
WHO. Zika Strategic response framework & joint operations plan January-June 2016. http://www. who.int/emergencies/zika-virus/strategic-response- framework.pdf
Padilla J, Rojas D, Sáenz-Gómez R. Dengue en Colombia: epidemiología de la reemergencia a la hiperendemia 2012. https://www.minsalud.gov. co/sites/rid/Lists/BibliotecaDigital/RIDE/INEC/INV/ Dengue%20en%20Colombia.pdf
Kolter T. Ganglioside Biochemistry. ISRN Biochem 2012;2012:1-36.
Svennerholm E, Svennerholm L. The separation of neutral blood-serum glycolipids by thin-layer chromatography. Biochim Biophys Acta 1963;70:432-41.
Vyas AA, Schnaar RL. Brain gangliosides: Functional ligands for myelin stability and the control of nerve regeneration. Biochimie 2001;83:677-82.
Schnaar RL, Gerardy-Schahn R, Hildebrandt H. Sialic acids in the brain: gangliosides and polysialic acid in nervous system development, stability, disease, and regeneration. Physiol Rev 2014;94:461-518.
Tettamanti G, Bonali F, Marchesini S, Zambotti V. A new procedure for the extraction, purification and fractionation of brain gangliosides. Biochim Biophys Acta (BBA)/Lipids Lipid Metab 1973;296:160-70.
Willison HJ, Yuki N. Peripheral neuropathies and anti-glycolipid antibodies. Brain 2002;125:2591–625.
Ilyas AA, Quarles RH, Dalakas MC, Fishman PH, Brady RO. Monoclonal IgM in a patient with paraproteinemic polyneuropathy binds to gangliosides containing disialosyl groups. Ann Neurol 1985;18:655-9.
Ilyas AA, Willison HJ, Quarles RH, Jungalwala FB, Cornblath DR, Trapp BD, et al. Serum antibodies to gangliosides in Guillain-Barré syndrome. Ann Neurol 1988;23:440-7.
O’Hanlon GM, Plomp JJ, Chakrabarti M, Morrison I, Wagner ER, Goodyear CS, et al. Anti-GQ1b ganglioside antibodies mediate complement-dependent destruction of the motor nerve terminal. Brain 2001;124:893-906.
Yu RK, Usuki S, Ariga T. Ganglioside molecular mimicry and its pathological roles in Guillain-Barré syndrome and related diseases. Infect Immun 2006;74:6517-27.
Brezovska K, Panovska AP, Grozdanova A, Su- turkova L, Basta I, Apostolski S. Immunoreactivity of glycoproteins isolated from human peripheral nerve and Campylobacter jejuni (O:19). J Neurosci Rural Pract 2011;2:125-9.
Yoshino H, Inuzuka T, Miyatake T. IgG antibody against GM1, GD1b and asialo-GM1 in chronic polyneuropathy following Mycoplasma pneumoniae infection. Eur Neurol 1992;32:28-31.
Khalili-Shirazi A, Gregson N, Gray I, Rees J, Winer J, Hughes R. Antiganglioside antibodies in Guillain-Barré syndrome after a recent cytomegalovirus infection. J Neurol Neurosurg Psychiatry 1999;66:376-9.
Rojas-García R, Querol L, Gallardo E, Salva NDL, Juarez C, Garces M, et al. Clinical and serological features of acute sensory ataxic neuropathy with antiganglioside antibodies. J Peripher Nerv Syst 2012;17:158-68.
Anaya J, Ramirez-Santana C, Salgado-Castaneda I, Chang C, Ansari A, Gershwin M. Zika virus and neurologic autoimmunity: the putative role of gangliosides. BMC Med 2016;14.
Lucchese G, Kanduc D. Zika virus and autoimmunity: From microcephaly to Guillain-Barré syndrome, and beyond. Autoimmun Rev 2016;15:801-8.
Anaya JM. Lecciones del Zika. El Espectador, Feb 9, 2016. http://www.elespectador.com/noticias/ciencia/ lecciones-del-zika-articulo-615592
Heymann DL, Liu J, Lillywhite L. Partnerships, not parachutists, for zika research. N Engl J Med 2016;374:1504-5.
Focosi D, Maggi F, Pistello M. Zika Virus: Implications for Public Health. Clin Infect Dis 2016;63:227-33.
Silva LR, Souza AM. Zika virus: what do we know about the viral structure, mechanisms of transmission, and neurological outcomes? Rev Soc Bras Med Trop 2016;49:267-73.
Willison HJ, Jacobs BC, van Doorn PA. Guillain- Barré syndrome. Lancet 2016. Feb 29 doi: 10.1016/ S0140-6736(16)00339-1.
Dick GW. Zika virus. II. Pathogenicity and physical pro- perties. Trans R Soc Trop Med Hyg 1952;46:521-34.
da Silva SR, Gao SJ. Zika virus update II: Recent development of animal models - proofs of association with human pathogenesis. J Med Virol 2016 May 21.
Palacios R, Poland GA, Kalil J. Another emerging arbovirus, another emerging vaccine: Targeting Zika virus. Vaccine 2016;34:2291-3.
Tripp RA, Ross T. Development of a Zika vaccine. Expert Rev Vaccines. 2016; 0584:14760584.2016.1192474.
Ferguson NM, Cucunubá ZM, Dorigatti I, Nedjati-Gilani GL, Donnelly CA, Basáñez MG, et al. Countering Zika in Latin America. Science. 2016 Jul 14.
Lwande OW, Obanda V, Bucht G, Mosomtai G, Otieno V, Ahlm C, et al. Global emergence of Alphaviruses that cause arthritis in humans. Infect Ecol Epidemiol 2015;5:29853.
Ministerio de Salud y Protección Social. Boletin de Prensa No 155 de 2016. https://www.minsalud.gov. co/Paginas/Colombia-primer-pais-del-continente- que-cierra-epidemia-de-zika.aspx
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